Erik ten Hag’s men currently find themselves rock bottom of Group A after failing to hold out against Galatasaray last time out.
But United can dramatically climb above Copenhagen and Galatasaray with a victory should their group rivals draw in the other fixture.
However, should there be a winner between Copenhagen and Galatasaray, they would progress with Bayern.
Bayern boss Thomas Tuchel could have been expected to rest several players having already booked a last-16 spot.
But he has demanded the Bavarians bounce back from their 5-1 Eintracht Frankfurt drubbing at the weekend and could play a very strong team.